申翼博士
主任医师
电话：025-80863012邮箱：dryishen@nju.edu.cn 地址：中山东路305号研究方向：

1.普胸肿瘤基础研究 2.普胸肿瘤外科微创治疗及临床研究 3.食管癌快速康复外科研究

  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

工作简历

1.1995年于韦德1946体育官方入口本硕连读毕业，获硕士学位；

2.2002-2005于第二军医大学，获博士学位；

3.1995年起于金陵医院心胸外科工作；

4.2005-2012年任金陵医院心胸外科副主任医师、科主任助理；

5.2013-2014年赴美国加州大学戴维斯医学中心任访问学者；

6.2012-2019年为金陵医院心胸外科主任医师、科室副主任；

7.2020年起任金陵医院心胸外科主任医师、科室主任。


科研情况简介

1.近年主持多项国家、军队科研课题，包括国家自然科学基金面上项目1项、江苏省自然科学基金面上项目2项、江苏省卫健委医学科研立项重点项目1项；

2.近年在Annals of Thoracic Surgery、Molecular Therapy-Nucleic Acids、Cancer Letters、Cell Death and Disease、Clinical Nutrition等杂志，以第一或通讯作者发表SCI论文60余篇。


研究兴趣

1.普胸肿瘤的基础研究：主要从事肺癌、食管癌发生发展与非编码RNA相关研究，以及肿瘤淋巴管、血管生成的分子机制；

2.临床研究：主要包括肺癌、食管癌、纵隔肿瘤的微创治疗，以及食管癌快速康复（ERAS）的临床研究工作。






金陵医院心胸外科行政主任、主任医师

金陵医院博士后联系导师、韦德1946体育官方入口博士生、硕士生导师

韦德1946体育官方入口食管癌研究所所长

美国加州大学戴维斯医学中心高级访问学者

江苏省医学会胸外科分会主任委员

江苏省研究型医院学会胸外科分会主任委员

江苏省医学会胸外科专委会常务委员

江苏省医师协会胸外科分会副会长

江苏抗癌协会食管癌专委会副主任委员

中国抗癌协会胸壁肿瘤专委会常务委员

南京市胸心血管外科学会副主任委员

中华医学会肠内肠外营养学会胸部疾病营养治疗协作组组长

中国医师协会外科医师分会机器人医师委员会委员

中国医药教育协会加速康复外科委员会委员

江苏省肿瘤专业委员会委员

江苏省医师协会肿瘤外科医师分会委员

江苏省医学会胸外科分会微创学组副组长

江苏省肿瘤委员会肺癌学组副组长

江苏省抗癌协会肿瘤微创治疗专业学会委员

江苏省微无创专业委员会委员

中国医药教育协会加速康复外科委员会委员

《中国胸心血管外科临床杂志》《中国体外循环杂志》《心血管外科杂志》《医学研究生学报》等编委

《Journal of Thoracic Disease》《Translatesurgery》《Asia-Pacific Journalof Medicine》《肿瘤学杂志》《实用肿瘤学杂志》等审稿专家

  1. Wang S, Song X, Song X, Gu Y, Cong Z, Shen Y and Yu L. Non-Invasive Brain-Computer Interfaces: Converging Frontiers in Neural Signal Decoding and Flexible Bioelectronics Integration. Nanomicro Lett. 2026;12;18(1):193.

  2. Wang Y, Ge Q, Zheng H, Luo J, Cong Z, Wang C and Shen Y. Effects of postoperative adjuvant therapy on prognosis for esophageal cancer patients after neoadjuvant therapy followed by esophagectomy: a systematic review and meta-analysis. Int J Surg. 2025 Dec 10.

  3. Qu W, Wang Z, Zhu T, Cui H, Bing Z, Shen S, Shen Y, Yu S, Zhuang H and Wang T. Aspergillus fumigatus promotes tumor angiogenesis via SLC7A11 on myeloid-derived suppressor cells. EMBO Rep. 2025;26(24):6266-6291.

  4. Wang H, Huang H, Li F, Deng Y, Wang C, Wei W, Wang S, Zhu D, Xu H, Bao H, Li Z, Ye W, Zhang Y, Li C, Cheng B, Liu X, Liu L, Li Z, Yang J, Chen W, He P, Wang F, Zhong W, Guo W, Shao Y, Shen Y, He J and Liang W. Risk-stratified classification of pulmonary nodule malignancy via a machine learning model integrating imaging and cell-free DNA: a model development and validation study (DECIPHER-NODL). Lancet Reg Health West Pac. 2025;12;64:101730.

  5. Huang Z, Zhao P, Qiu B, Gao C, Chen Z, Yang N, Xu Y, Zou Z, Shen Y and Hu L. Effects of the lavage through fistula in treatment of spontaneous esophageal rupture by combined thoracoscopic and gastroscopic management. World J Emerg Surg. 2025;7;20(1):51.

  6. Zheng C, Zhang GC, Zhang L, Zhang YZ, Jia J, Xu S, Zhao WY, Liu Y, Yue M, Liu YP, Zhang SP, Shen Y, Ge QY, Han YN, Li J, Yan HJ, Xue LY, Gao YS, Tan FW, Gao SG, Xue Q and He J. Identification of the lymph node metastasis atlas and optimal lymph node dissection strategy in patients with resectable lung invasive mucinous adenocarcinoma: a real-world multicenter study. Mil Med Res. 2025;15;12(1):67.

  7. Zheng HT, Wang CY, Luo J, Wu YH, Ge QY, Cong ZZ and Shen Y. Endoscopic treatment versus surgical treatment for T1b esophageal cancer: a systematic review and meta-analysis. Eur J Surg Oncol. 2025;51(8):110094.

  8. Zheng S, Zhou Z, Ji J, Liu Y, Jiao X, Li X, Shen Y, Hong H and Han X. M2 macrophage-targeted metal-polyphenol networks (MPNs) for OPN siRNA delivery and idiopathic pulmonary fibrosis therapy. J Control Release. 2025;10;383:113862.

  9. Ge QY, Zheng C, Song XB, Cong ZZ, Luo J, Zheng HT, Zhao PL, Wang YQ, Chen BW and Shen Y. The Relationship Between the Average Infusion Rate of Propofol and the Incidence of Delirium During Invasive Mechanical Ventilation: A Retrospective Study Based on the MIMIC IV Database. CNS Neurosci Ther. 2025;31(3):e70273. 

  10. Xu H, Ding S, Ning X, Ma Y, Yu Q, Shen Y, Han L and Xu Z. Integrated bioinformatics and validation reveal TMEM45A in systemic lupus erythematosus regulating atrial fibrosis in atrial fibrillation. Mol Med. 2025; 18;31(1):104. 

  11. Hu L, Xie K, Zheng C, Qiu B, Jiang Z, Luo C, Diao Y, Luo J, Yao X and Shen Y. Exosomal MALAT1 promotes the proliferation of esophageal squamous cell carcinoma through glyoxalase 1-dependent methylglyoxal removal. Noncoding RNA Res. 2024;10;9(2):330-340. doi: 10.1016/j.ncrna.2024.01.003.

  12. Li X, Luan S, Zhang C, Kong W, Xiao X, Zhang H, Zhou J, Yang Y, Xu Y, Qiang Y, Fang P, Shen Y and Yuan Y. A novel tumor staging system incorporating cN status for stratifying early stage esophageal squamous cell carcinoma patients after trimodal therapy. Eur J Surg Oncol. 2024;50(1):107264.

  13. Ji J, Zheng S, Liu Y, Xie T, Zhu X, Nie Y, Shen Y and Han X. Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis. J Transl Med. 2023;19;21(1):640.

  14. Wei L, Hu N, Ye M, Xi Z, Wang Z, Xiong L, Yang N and Shen Y.   Overexpression of 14-3-3zeta primes disease recurrence, metastasis and   resistance to chemotherapy by inducing epithelial-mesenchymal transition in   NSCLC. Aging (Albany NY). 2022;14:5838-5854.

  15. Zheng C, Li XK, Zhang C, Zhou H, Ji SG, Zhong JH, Xu Y, Cong   ZZ, Wang GM, Wu WJ and Shen Y. Comparison of short-term clinical outcomes   between robot-assisted minimally invasive esophagectomy and video-assisted   minimally invasive esophagectomy: a systematic review and meta-analysis. J   Thorac Dis. 2021;13:708-719.

  16. Yang J, Sun H, Tian F, Wan S, Mamtawla G, Wang P, Gao X, Zhang   L, Li J, Shen Y and Wang X. Autophagy suppression plays a role in parenteral   nutrition-associated lung injury. Clin Nutr. 2021;40:560-570.

  17. Shao CY, Yu Y, Li QF, Liu XL, Song HZ, Shen Y and Yi J.   Development and Validation of a Clinical Prognostic Nomogram for Esophageal   Adenocarcinoma Patients. Front Oncol. 2021;11:736573.

  18. Luo J, Wang H, Wang L, Wang G, Yao Y, Xie K, Li X, Xu L, Shen   Y and Ren B. lncRNA GAS6-AS1 inhibits progression and glucose metabolism   reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1.   Mol Ther Nucleic Acids. 2021;25:11-24.

  19. Li XK, Xu Y, Zhou H, Cong ZZ, Wu WJ, Qiang Y and Shen Y. Does   robot-assisted minimally invasive oesophagectomy have superiority over   thoraco-laparoscopic minimally invasive oesophagectomy in lymph node   dissection? Dis Esophagus. 2021;34.

  20. Xu Y, Li XK, Cong ZZ, Zhou H, Wu WJ, Qiang Y, Yi J and Shen Y.   Long-term outcomes of robotic-assisted versus thoraco-laparoscopic McKeown   esophagectomy for esophageal cancer: a propensity score-matched study. Dis   Esophagus. 2020.

  21. Luo J, Xie K, Gao X, Yao Y, Wang G, Shao C, Li X, Xu Y, Ren B,   Hu L and Shen Y. Long Noncoding RNA Nuclear Paraspeckle Assembly Transcript 1   Promotes Progression and Angiogenesis of Esophageal Squamous Cell Carcinoma   Through miR-590-3p/MDM2 Axis. Front Oncol. 2020;10:618930.

  22. Li XK, Xu Y, Cong ZZ, Zhou H, Wu WJ and Shen Y. Comparison of   the progression-free survival between robot-assisted thymectomy and   video-assisted thymectomy for thymic epithelial tumors: a propensity score   matching study. J Thorac Dis. 2020;12:4033-4043.

  23. Li XK, Xu Y, Cong ZZ, Luo J, Zhou H, Ji SG, Diao YF, Wu WJ, Qiang   Y, Qian JJ and Shen Y. Modified Collard versus end-to-side hand-sewn   anastomosis for cervical anastomosis after McKeown esophagectomy. Thorac   Cancer. 2020;11:2909-2915.

  24. Li XK, Cong ZZ, Xu Y, Zhou H, Wu WJ, Wang GM, Qiang Y and Shen Y.   Clinical efficacy of robot-assisted thoracoscopic surgery for posterior   mediastinal neurogenic tumors. J Thorac Dis. 2020;12:3065-3072.

  25. Li XK, Cong ZZ, Wu WJ, Ji SG, Zhou H, Liu KC, Xu Y and Shen Y.   Efficacy of 4 wk of home enteral feeding supplementation after esophagectomy   on immune function: A randomized controlled trial. Nutrition. 2020;77:110787.

  26. Cong Z, Diao Y, Li X, Jiang Z, Xu Y, Zhou H, Qiang Y, Wu H and   Shen Y. Long non-coding RNA linc00665 interacts with YB-1 and promotes   angiogenesis in lung adenocarcinoma. Biochem Biophys Res Commun.   2020;527:545-552.

  27. Cao H, Chen X, Hou J, Wang C, Xiang Z, Shen Y and Han X. The   Shh/Gli signaling cascade regulates myofibroblastic activation of   lung-resident mesenchymal stem cells via the modulation of Wnt10a expression   during pulmonary fibrogenesis. Lab Invest. 2020;100:363-377.

  28. Luo J, Yao Y, Ji S, Sun Q, Xu Y, Liu K, Diao Q, Qiang Y and Shen   Y. PITX2 enhances progression of lung adenocarcinoma by transcriptionally   regulating WNT3A and activating Wnt/beta-catenin signaling pathway. Cancer   Cell Int. 2019;19:96.

  29. Luo J, Liu K, Yao Y, Sun Q, Zheng X, Zhu B, Zhang Q, Xu L, Shen Y   and Ren B. DMBX1 promotes tumor proliferation and regulates cell cycle   progression via repressing OTX2-mediated transcription of p21 in lung   adenocarcinoma cell. Cancer Lett. 2019;453:45-56.

  30. Cong Z, Diao Y, Xu Y, Li X, Jiang Z, Shao C, Ji S, Shen Y, De W and   Qiang Y. Long non-coding RNA linc00665 promotes lung adenocarcinoma   progression and functions as ceRNA to regulate AKR1B10-ERK signaling by   sponging miR-98. Cell Death Dis. 2019;10:84.

  31. Luo J, Wang Z, Huang J, Yao Y, Sun Q, Wang J, Shen Y, Xu L and Ren   B. HOXC13 promotes proliferation of esophageal squamous cell carcinoma via   repressing transcription of CASP3. Cancer Sci. 2018;109:317-329.

  32. Hu L, Yao X, Huang H, Guo Z, Cheng X, Xu Y, Shen Y, Xu B and Li   D. Clinical significance of germline copy number variation in susceptibility   of human diseases. J Genet Genomics. 2018;45:3-12.

  33. Cong Z, Diao Q, Yi J, Xiong L, Wu H, Qin T, Jing H, Li D and Shen   Y. Esophagectomy combined with aortic segment replacement for esophageal   cancer invading the aorta. Ann Thorac Surg. 2014;97:460-6.



  1. 江苏省自然科学基金面上项目，能量应激诱导的长链非编码RNA LINC01207通过调节肿瘤糖代谢重塑促进肺腺癌恶性进展的机制研究，2025.09-2028.08。

  2. 江苏省卫健委医学科研立项重点项目，基于血清外泌体lncRNA标志物的肺腺癌脑转移无创诊断及转移机制的研究，2022.01-2024.12。

  3. 江苏省自然科学基金面上项目，长链非编码RNA HOXC13-AS作为增强子样元件调控食管癌恶性特征的机制研究，2019.01-2021.12。

  4. 国家自然科学基金面上项目，SDF-1/CXCR4诱导淋巴管内皮祖细胞在肺鳞癌组织中形成新生淋巴管的机制研究，2012.01-2015.12。

  1. 2025年江苏医学科技奖二等奖（1/7）

  2. 2022年中国人民解放军科技进步三等奖（1/5）

  3. 2021年度江苏省卫健委医学引进新技术二等奖（1/3）

  4. 2009年中国人民解放军医疗成果二等奖（5/9）

  5. 2008年江苏省科技进步奖三等奖（5/7）