曲乐，东部战区总医院泌尿外科副主任、副主任医师、副教授、韦德1946体育官方入口博士生导师，教育部青年长江学者。2006-2016年于海军军医大学完成临床医学本科（2006-2011）、泌尿外科硕士（2011-2013）及博士（2013-2016）系统培养，2016年入职东部战区总医院，历任泌尿外科主治医师（2016-2021）、副主任医师（2021至今），2021年起任韦德1946体育官方入口副教授。中国抗癌协会青年科学家奖、江苏省杰出青年基金、江苏省333高层次人才培养工程（第二层次）获得者，荣立个人和集体三等功各一次。长期聚焦肾脏肿瘤的精准诊疗和转化研究，在Cancer Cell、European Urology(x2)、Nature Communications、 Science Advances等杂志发表SCI论文数十篇，总被引2000余次，取得了一系列具有临床转化前景的研究成果，并开展试剂盒研发和临床试验，全力推动肾脏肿瘤的科研成果转化，获中国医师协会年度最佳临床研究论文奖。荣获全军优秀博士论文，江苏医学科技奖一等奖、教育部科技进步奖一等奖和国家科学技术进步奖二等奖。获国家发明专利授权5项。主持国家重点研发计划子课题、国家自然科学基金面上项目3项、博士后创新人才支持计划，江苏省六大人才高峰等课题。受英国皇家外科学院邀请，参编英文专著《Kidney cancer》，并作为副主编出版国内第一部肾脏肿瘤专著《肾脏肿瘤外科学》。任中华医学会泌尿外科分会基础学组委员，中国研究型医院学会泌尿外科学专业委员会委员，中国人民解放军联勤保障部队青年指导专家委员会常委，江苏省抗癌协会泌尿男生殖系专业委员会委员，江苏省医师协会泌尿外科医师分会委员以及江苏省肾癌协作组秘书，参与制定《机器人辅助腹腔镜囊性肾肿瘤肾部分切除术专家共识》，任《医学研究与战创伤救治》、《国际泌尿系统杂志》及《Clinical Genitourinary Cancer》编委。

中华医学会泌尿外科分会基础学组委员

江苏省抗癌协会泌尿男生殖系专业委员会委员

江苏省医师协会泌尿外科医师分会委员

《国际泌尿系统杂志》、《Clinical Genitourinary  Cancer》及《Chinese Medical Journal》编委。

1.Le Qu^#, Jin Ding^#, Cheng Chen^#, Zhenjie Wu^#, Bing Liu^#, Yi Gao, Wei Chen, Feng Liu, Wen Sun, Xiaofeng Li, Xue Wang, Yue Wang, Zhenyu Xu, Li Gao, Qing Yang, Bin Xu, Yaoming Li, Ziyu Fang, Zhipeng Xu, Yi Bao, Dengshuang Wu, Xiong Miao, Haiyang Sun, Yinghao Sun, Hongyang Wang*, Linhui Wang*, Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-668. (IF: 31.743)

2.Le Qu^#, Zhenjie Wu^#, Yaoming Li^#, Zhipeng Xu^#, Bing Liu, Feng Liu, Yi Bao, Dengshuang Wu,Jiayi Liu, Anbang Wang, Xiaoyuan Chu, Yinghao Sun, Cheng Chen*, Zhengyu Zhang*, Linhui Wang*. A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Nature Communications. 2016 Nov 25;7:12692. (IF: 17.694)

3.Dengshuang Wu^#, Cheng Chen^#, Zhenjie Wu^#, Bing Liu, Li Gao, Qing Yang, Wei Chen, Junming Chen, Yi Bao, Le Qu*, Linhui Wang*. ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma. Journal of Experimental & Clinical Cancer Research. 2016 Jul 4;35(1):108.(IF: 9.867)

4.Zhipeng Xu^#, Peng Li^#, Dan Wei^#, Zhixiang Wang, Yi Bao, Jipeng Sun, Le Qu*, Linhui Wang*. NMMHC-IIA-dependent nuclear location of CXCR4 promotes migration and invasion in renal cell carcinoma. Oncology Reports. 2016 Nov;36(5):2681-2688. (IF: 4.136)

5.Jiakuan Li^#, Cheng Chen^#, Jiayi Liu^#, Jiazi Shi^#, Shupeng Liu^#, Bing Liu, Dengshuang Wu, Ziyu Fang, Yi Bao, Mingming Jiang, Jihang Yuan*,Le Qu*, Lin-Hui Wang*. Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling. Molecular Cancer. 2017 Jun 28;16(1):111. (IF: 41.444)

6.Xiao-Feng Li^#, Cheng Chen^#, Dai-Min Xiang^#, Le Qu#, Wen Sun, Xin-Yuan Lu, Teng-Fei Zhou, Shu-Zhen Chen, Bei-Fang Ning, Zhuo Cheng, Ming-Yang Xia, Wei-Feng Shen, Wen Yang, Wen Wen, Terence Kin Wah Lee, Wen-Ming Cong, Hong-Yang Wang*, Jin Ding*. Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance. Hepatology. 2017 Dec;66(6):1934-1951. (IF: 17.298)

7.Anbang Wang^#, Le Qu*, Linhui Wang*, At the crossroads of cancer stem cells and targeted therapy resistance. Cancer Letters. 2017 Jan 28;385:87-96. (IF: 9.756)

8.Zhipeng Xu^#, Fu Yang^#, Dan Wei^#, Bing Liu, Cheng Chen, Yi Bao, Zhenjie Wu, Dengshuang Wu, Haisong Tan, Jiakuan Li, Jie Wang, Jiayi Liu, Shuhan Sun*, Le Qu*, Linhui Wang*. Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. Oncogene. 2017 Apr 6;36(14):1965-1977. (IF: 8.756)

9.Le Qu^#/*, Zelin Wang^#, Qi Chen^#, Yaoming Li^#, Haowei He^#, James J Hsieh, Song Xue, Zhenjie Wu, Bing Liu, Hao Tang, Xiaofeng Xu, Feng Xu, Jie Wang, Yi Bao, Anbang Wang, Dong Wang, Xiaoming Yi, Zhongkui Zhou, Changjie Shi, Ke Zhong, Zhengcheng Sheng, Yulin Zhou, Jun Jiang, Xiaoyuan Chu, Jia He, Jingping Ge, Zhengyu Zhang, Wenquan Zhou*, Cheng Chen*, Jianhua Yang*, Yinghao Sun*, Linhui Wang*. Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma. European Urology. 2018 Dec;74(6):756-763. (IF: 24.267)

10.Yi Bao^#, Fu Yang^#, Bing Liu^#, Tangliang Zhao^#, Zhipeng Xu^#, Ying Xiong, Shuhan Sun*, Le Qu* and Linhui Wang*. Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response. British journal of cancer. 2018 Aug;119(4):450-461. (IF: 9.075)

11.Anbang Wang^#, Yi Bao^#, Zhenjie Wu^#, Tangliang Zhao^#, Dong Wang^#, Jiazi Shi, Bing Liu, Shuhan Sun, Fu Yang*, Linhui Wang*, Le Qu*. Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. Cell Death Disease. 2019 Feb 15;10(3):154. (IF: 9.685)

12.Bowen Du^#, Yulin Zhou^#, Xiaoming Yi, Tangliang Zhao, Chaopeng Tang, Tianyi Shen, Kai Zhou, Huixian Wei, Song Xu*, Jie Dong*, Le Qu*, Haowei He* and Wenquan Zhou. Identification of Immune-Related Cells and Genes in Tumor Microenvironment of Clear Cell Renal Cell Carcinoma. Frontiers in Oncology, 2020, 10: 1770. (IF: 12.658)

13.Yicun Wang^#, Jinhui Wu^#, Hui Chen^#, Yang Yang^#, Chengwu Xiao^#, Xiaoming Yi^#, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang , Xiaodie Zhou , Gwen Lomberk , Bing Liu , Jianning Zhao , Jingping Ge, Wenquan Zhou*, Xiaoyuan Chu*, Cheng Chen*, Xuhui Zhou*, Linhui Wang*, Kunliang Guan, Le Qu*. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Science Advances. 2021 Jan 27; EABE3445 (IF: 14.957)

14.Zhenjie Wu^#, Qi Chen^#, Le Qu*, Mingmin Li*, Linhui Wang*, Maria C. Mir, Umberto Carbonara, Savio D. Pandolfo, Peter C. Black, Asit K Paul, Giuseppe Di Lorenzo, Francesco Porpiglia, Andrea Mari, Andrea Necchi, Morgan Roupret, Sarah P. Psutka, Riccardo Autorino. Adverse Events of Immune Checkpoint Inhibitors therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-Analysis. European Urology. 2022 Jan 28; S0302-2838(22)00065-3. (IF: 24.267)

15.Aimin Jiang^#, Jialin Meng^#, Wenliang Gong^#, Zhonghua Zhang^#, Xinxin Gan, Jie Wang, Zhenjie Wu, Bing Liu*, Le Qu*, Linhui Wang*. Elevated SNRPA1, as a promising predictor reflecting severe clinical outcome via effecting tumor immunity for ccRCC, is related to cell invasion, metastasis and Sunitinib sensitivity. Frontiers in Immunology. 2022; February; 13; fimmu.2022.842069 (IF: 8.786)

16.Le Qu^#, Hui Chen^#, Qi Chen^#, Silun Ge^#, Aimin Jiang^#, Nengwang Yu^#, Yulin Zhou, Michał Kunc, Ye Zhou, Xiang Feng, Wei Zhai, Zhenjie Wu, Miaoxia He, Yaoming Li, Rui Chen, Bo Han, Xing Zeng, Yao Fu, Changwei Ji, Xiang Fan, Guangyuan Zhang, Cheng Zhao, Taile Jing, Chenchen Feng, Hongwei Zhao, Di Sun, Liang Wang, Sheng Tai, Cheng Zhang, Shaohao Chen, Yixun Liu, Haifeng Wang, Jinli Gao, Yufeng Gu, He Miao, Tangliang Zhao, Xiaoming Yi, Chaopeng Tang, Dian Fu, Haowei He, Qiu Rao, Wenquan Zhou, Ning Xu, Gongxian Wang, Chaozhao Liang, Zhiyu Liu, Dan Xia, Xiongbing Zu, Ming Chen, Hongqian Guo, Weijun Qin, Zhe Wang, Wei Xue, Benkang Shi, Shaogang Wang, Junhua Zheng, Cheng Chen, Łukasz Zapała, Jingping Ge, Linhui Wang. Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study. MedComm. 2023 Jul 20;4(4):e300. (IF:10.7)

17.Zhenjie Wu^#, Hui Chen^#, Qi Chen^#, Silun Ge^#, Nengwang Yu^#, Riccardo Campi, Juan Gómez Rivas, Riccardo Autorino, Morgan Rouprêt, Sarah P Psutka, Reza Mehrazin, Francesco Porpiglia, Karim Bensalah, Peter C Black, Maria C Mir, Andrea Minervini, Hooman Djaladat, Vitaly Margulis, Riccardo Bertolo, Anna Caliò, Umberto Carbonara, Daniele Amparore, Leonardo D Borregales, Chiara Ciccarese, Pietro Diana, Selcuk Erdem, Laura Marandino, Michele Marchioni, Constantijn H J Muselaers, Carlotta Palumbo, Nicola Pavan, Angela Pecoraro, Eduard Roussel, Hannah Warren, Savio Domenico Pandolfo, Rui Chen, Wenquan Zhou, Wei Zhai, Miaoxia He, Yaoming Li, Bo Han, Jie Wan, Xing Zeng, Junan Yan, Yao Fu, Changwei Ji, Xiang Fan, Guangyuan Zhang, Cheng Zhao, Taile Jing, Anbang Wang, Chenchen Feng, Hongwei Zhao, Di Sun, Liang Wang, Sheng Tai, Cheng Zhang, Shaohao Chen, Yixun Liu, Zhipeng Xu, Haifeng Wang, Jinli Gao, Fubo Wang, Jiwen Cheng, He Miao, Qiu Rao, Jianning Wang, Ning Xu, Gongxian Wang, Chaozhao Liang, Zhiyu Liu, Dan Xia, Jun Jiang, Xiongbing Zu, Ming Chen, Hongqian Guo, Weijun Qin, Zhe Wang, Wei Xue, Benkang Shi, Xiaojun Zhou, Shaogang Wang, Junhua Zheng, Jingping Ge, Xiang Feng, Minming Li, Cheng Chen, Le Qu, Linhui Wang; REMEMBER Consortium and the European Association of Urology Young Academic Urologists Renal Cancer Working Group. Prognostic Significance of Grade Discrepancy Between Primary Tumor and Venous Thrombus in Nonmetastatic Clear-cell Renal Cell Carcinoma: Analysis of the REMEMBER Registry and Implications for Adjuvant Therapy. Eur Urol Oncol. 2024 Feb;7(1):112-121. (IF:9.3)

1. 国家自然科学基金面上项目，82373154，2024/01-2027.12。

2. 国家自然科学基金面上项目，82173345，2022/01-2025-12。

3. 国家自然科学基金面上项目，81772740，2018/01-2021-12。

4. 江苏省杰出青年基金项目，BK20200006，2020/07-2023/06。

5. 江苏省自然科学基金青年基金，BK20170621，2017/07-2020/06。

6. 江苏省第十六批“六大人才高峰”高层次人才，YY-093，2020/01-2022/12。

7. 博士后创新人才支持计划，BX201700105，2017/05-2019/05。

8. 中国博士后科学基金面上项目，2018M643886，2018/07-2019/06。

9. 江苏省博士后科研资助计划，2018K289C，2018/01-2020/01。

2024年上海市科学技术奖一等奖

2023年江苏医学科技奖一等奖

2023年中国抗癌协会青年科学家奖

2020年江苏省杰出青年基金项目

2019年教育部“长江学者奖励计划”青年学者

2019年江苏省“六大人才高峰”高层次人才

2018年国家科学技术进步奖，二等奖（第三完成人）

2017年教育部科技进步奖，一等奖（第六完成人）

2016年全军优秀博士论文